Alto Neuroscience's experimental depression drug, ALTO-100, failed to show significant improvement over a placebo in a recent trial, leading to a two-thirds drop in the company's share price. Despite this setback, analysts maintain that the company's biomarker-driven approach to drug development still holds promise, with additional data expected from other studies by 2027. Alto has sufficient funds to continue operations and explore other therapeutic avenues.
Wave Life Sciences has reported promising early results from its RNA editing treatment for alpha-1 antitrypsin deficiency (AATD), showing significant increases in AAT protein levels in two patients. This marks a milestone in therapeutic RNA editing, with no serious side effects observed. The findings have boosted investor confidence, leading to a 75% rise in Wave's shares, while GSK prepares to take over development under their partnership.
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